Proteoshape analysis on the Nautilus Proteome Analysis Platform

Although it is commonly stated that there are approximately 20,000 proteins encoded in the human genome, these 20,000 proteins can be modified in many ways to produce potentially millions of proteoforms with altered functions, localizations, half-lives, and more. Each proteoform is defined by the full set of modifications it has, regardless of whether these modifications come from alternative splicing, post-translational modification, or any other source. Thus, identifying proteoforms requires single-molecule analysis of full-length proteins.

Knowing the proteoform composition of a cell, tissue or organism can reveal the molecular basis of its biology and allow scientists to develop more effective biomarkers and drugs. In this animation, we demonstrate how the Nautilus Proteome Analysis Platform is uniquely designed to enable single-molecule analysis of intact proteoforms for in-depth studies of proteoform biology not possible on other platforms.

Chapters
00:28 – What are proteoforms?
01:29 – Quantifying proteoforms on the Nautilus Proteome Analysis Platform
02:48 – Applications of proteoform analyses

Which aspects of proteoform biology would you particularly like to know more about? Let us know in the comments below.

Read more about proteoforms on our blog:
https://www.nautilus.bio/blog/what-are-proteoforms/
https://www.nautilus.bio/blog/targeted-proteoform-studies-on-the-nautilus-platform/

Watch this animation to learn more about large-scale proteomic analysis on the Nautilus platform:
https://youtu.be/pWpN5BL3nwg?si=ate-sdT4CaOKjspb

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